HPMC is very sensitive to temperature and exhibits significant differences in dissolution characteristics at different temperatures. Therefore, it is necessary to control the water temperature to prevent sudden changes in viscosity or incomplete dissolution.HPMC usually disperses better in cold water, while it tends to swell or agglomerate in hot water.
Solution:
Avoid using high temperature to dissolve HPMC directly. It is recommended to use cold water dispersion method, or use warm water to stir first, and then gradually add cold water to adjust to the appropriate temperature (about 20-30℃).
If hot water must be used, dispersing HPMC in a small amount of hot water first, and then adding cold water to lower the temperature, to prevent a sudden increase in viscosity or the formation of a gel.
It is most effective to control the water temperature at room temperature (20-25℃), which can speed up the dissolution rate and ensure the stability of the solution.